Miniature Swine Diabetes Models and Services

The Diabetic Miniature Swine is a widely recognized, translationally relevant model for evaluation of drugs, nutritional therapies, devices and various therapeutic approaches to treatment of diabetes and its complications. Sinclair Research Center has been producing and working with Diabetic Miniature Swine since 2001. We offer a wide variety of research services using diabetic models and make Diabetic Miniature Swine available to industry and academic clients through Sinclair BioResources at www.sinclairbioresources.com.

Miniature Swine Diabetic Model Flexibility

The Diabetic Miniature Swine is a highly flexible model with a variety of applications. It can be maintained for long periods with standard insulin-mediated blood glucose control between studies.

Diabetic Miniature Swine Models

  • Type 1 (IDDM)
  • Models of Type 2 (NIDDM) complications

Miniature Swine Lineages for Diabetes

  • Yucatan
  • Sinclair
  • Micro-Yucatan

Applicable Research Areas

  • Type 1
  • Diabetic wounds
  • Obesity
  • Dyslipidemia
  • Atherosclerosis
  • Hypercholesterolemia
  • Ocular (cataracts, retinopathy)
  • Insulin resistance
  • Hypertension
  • Cardiometabolic syndrome

Therapy Types

  • Insulins, Insulin sensitizers, β-cell multipliers
  • Cellular therapies
  • Small and large molecules
  • Compounds targeting glucose and lipid activity

Collaboration/Consultation

  • Dr. M Michael Swindle, MUSC

Study Capabilities

  • PK/PD, Efficacy, Toxicology
  • IVGTT, OGTT
  • Glycemic Test
  • Hyperglycemic and Euglycemic Clamps
  • Bergman model
  • Wound Healing studies in Diabetic Miniature Swine
  • DEXA imaging for body composition for obesity
  • Dedicated colonies of Diabetic Miniature Swine

Support Personnel/Equipment, Facilities and Services

  • Five DVMs
  • 8 Vet Techs
  • Dedicated diabetes induction scientists
  • Study Directors specializing in diabetes studies
  • Four surgical suites
  • Wound Specialists
  • Vascular (VAP) placement surgery and maintenance
  • Post induction stabilization and long term maintenance for repeat studies
  • GLP-compliant, AAALAC accredited since 1994

Additional Information

  • Technical literature searches, peer reviewed papers
  • Diabetes fact sheet
Additional Resources:
 Printable Literature Sheet
Contact us to learn how we can accelerate your diabetes product development:
573 387 4400
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