Metabolism & Pharmacokinetics

Sinclair Research Center provides GLP-compliant In Vivo DMPK services from discovery through development in our state-of-the-art facility near Columbia, Missouri.

Drug Discovery/Drug Development

• Radiolabeled and Non-Radiolabeled Test Articles
• Pharmacodynamics
• Blood, Plasma, and Tissue Concentration
• Biliary Excretion (mouse, rat, dog)
• Mass Balance/Excretion (14C & 3H)
• Volatile Collection
• QWBA (In Vivo at Sinclair, Sectioning and Analysis Subcontracted)
• Metabolic Caging for Multiple Species (rodent, cat, dog, goat, swine)

Pharmacokinetics/Toxicokinetics

• Pharmacokinetics/Toxicokinetics
• Bioequivalence & Bioavailability
• Single or Multiple Dosing (In-life)
• PK/TK Analysis
• IVGTT, OGTT, & Glucose Clamps
• Meal Interference/Glycemic Challenge

Routes of Dose Administration

• Parenteral (IV/SC/IM/IP)
• Ocular
• IV Infusion
• Auricular
• Intranasal
• Rectal/Intravaginal
• Dermal/Intradermal/Transdermal patch
• Oral (gavage/liquid/ tablet/capsule)
• Vascular Access Ports (VAP)
• Intracoronary/Intraventricular (percutaneous access)
• Rodent Vascular and Non-Vascular Cannulas

Test Facility

• AAALAC Accredited Facility – Since 1995
• High Capacity for Small and Large Animals
• Rodents (Mouse, Rat, Hamster)
• Rabbits
• Canines
• Felines
• Domestic and Miniature swine (Sinclair, Yucatan, Hanford)
• Other Species Available

Analytical Support – Alliance Partner Service

• Discovery and GLP-compliant bioanalytical chemistry services (SRC Alliance Partner, ABC Laboratories)
• Sample Analysis-Routine Bioanalysis
  • Quantitative Analysis of Drug and Metabolites in Biological Matrices
  • Dose Formulation Analysis, Interference Testing
• Analytical Method Development, Validation (Full, Cross, & Partial), Method Transfer & Sample Analysis (LC-MS/MS, HPLC, ICP-MS, EIA, RIA, CZE, and Immunoblots)
• Dose Analysis (Radiochemical Purity, Specific Activity)
• Metabolite Characterization & Identification
• In addition to 14C labeling ABC Laboratories has experience with the following isotopes:
  • ³H, ³⁵S, ³²P, ⁹⁰Y, ¹¹¹In, ¹⁶⁶Ho, ¹⁸⁸Re, ^99mTc, and others.
• Immunoassays
  • ELISA and RIA (125I)
  • Method Development and Validation, Routine Sample Analysis
• SRC can also work with the Sponsor’s in-house analytical laboratory or with a Sponsor designated analytical laboratory in support of the studies.

Additional Resources:

 Literature Sheet