Toxicology
Sinclair Research Center provides GLP-compliant general toxicology services in our new state-of-the-art facility near Columbia, Missouri.
Toxicology Services
- Non-GLP (Discovery) and GLP Studies
- Pilot/Range Finding Studies
- Acute/Single Dose/MTD
- 14-Day and 28-Day Repeat Dose
- Sub-chronic and Chronic Exposures
- Rodent and Non-Rodent
- Repeat-Dose Dermal Irritation in Minipigs
- Target Animal Safety Studies
- FDA Redbook Feeding Trials
Test Facility
- AAALAC Accredited Facility Since 1995
- High Capacity for Small and Large Animals
- Rodents
- Canines
- Miniature Swine (Sinclair, Yucatan, Hanford)
- Non-Human Primates
- Rabbits
- Felines
- Housing for Other Species Available (goat, sheep, horses)
Routes of Dose Administration
- Parenteral (IV/SC/IM/IP)
- IV Infusion
- Ocular
- Rectal/Intravaginal
- Intranasal
- Auricular
- Oral (gavage/liquid/ tablet/capsule)
- Dermal/Intradermal/Transdermal patch
- Intracoronary/Intraventricular
- Vascular Access Ports (VAP)(percutaneous access)
Supporting Components for Toxicology Studies
- Toxicokinetics
- GLP-Compliant Clinical Pathology
- Board Certified Veterinary Ophthalmologist
- Small and Large Animal Necropsy Suite
- Board Certified Veterinary Cardiologist
- Board Certified Veterinary Pathobiologist for Histopathology