Animal Models

Sinclair Research has a strong commitment to supporting research and development programs of the biopharmaceutical industry. Over the past ten years, we have contributed to the development of multiple large animal models of human diseases; we are the only private contract research organization primarily involved in large animal model development.

Sinclair takes pride in the fact that we have developed and validated preclinical animal models for surgical studies, osteopenia, diabetes, inflammation, dermal toxicology, pharmacokinetics, and many other uses. Animal models available to our clients include:

  • Spontaneous Regressing Malignant Melanoma in Miniature Swine
  • White Hairless Miniature Swine for Dermal Studies
  • Spontaneous Ventricular Septal Defect (VSD) in Miniature Swine
  • Major Histocompatibility Complex (MHC)-Defined Miniature Swine Lineages for Transplantation
  • Large Animal Models of Type I and II Diabetes
  • Osteoporosis
  • Orthopedic Modeling and Bone Healing
  • Cardiovascular Disease and Atherosclerosis
  • Obesity and Weight Management
  • Surgical Models of Many Types, Including Wound Healing
  • Functional Observational Battery (FOB) in Miniature Swine

Major Use of Animal Models By Category of Research or Testing

 Animal Model Species Toxicology / Safety Pharmacology / PK / PD/ Metabolism / Biodistribution Inflammatory Disease / Vaccines Dermal Diabetes / Metabolic Disease Ortho- pedics Surgical Medical Devices TAS / Animal Health Palata- bility / Nutrition Other
Cynomologus NHP  X  X  X  X  X  X  X Pharm Safety
Yucatan Miniswine  X  X  X  X  X  X  X  X Wounds
Hanford Miniswine  X  X  X  X  X Wounds, CV
Sinclair Miniswine  X  X  X  X  X Hemostasis, Wounds,
Beagle  X  X  X  X  X  X  X  X  X  X
Hound  X  X  X  Dental
Cat  X  X  X  X  X  X
Sheep  X  X  X  X  X
Goat  X  X
Rabbits  X  X  X  X  X  X  X Ocular
Rat  X  X  X  X  X  X
Nude Rat  X  X
Mouse  X  X X  X  X  X
Nude Mouse  X  X  X  X  X Transplant
Guinea Pig  X  X
Hamster  X  X
Ferrets  X  X  X  X
Horses  X  X
Cattle  X  X  X
Poultry  X  X  X

TAS=Target Animal Safety, PK=Pharmacokinetics, PD=Pharmacodynamics, CV=Cardiovascular

Sinclair BioResources

BioLogoVectorNObgSinclair BioResources, our on-site sister company, has produced miniature swine since 1964 and has been a preclinical animal model production corporation since 1994. They are the largest miniature swine producer in the United States.

Miniature swine are specially selected to meet specific research project requirements. Sinclair BioResources is very experienced in pre-shipping pharmacological or surgical alterations, including but not limited to vascular access ports placement, high-cholesterol diet feeding, diabetes induction, test article administration, and biopsy collection for autotransplantation. They also provide an array of in vitro biosamples from miniature swine, as well as from rodents, cats, dogs, goats, and sheep.

 

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