Miniature Swine Production Tailored to the Research Community

Based on 40 years of swine production experience, Sinclair's production facility is designed around a revolutionary production system tailored specifically for the special needs of the miniature swine. An integrated socialization and enrichment program provides human and conspecific contacts and environmental enhancements. Husbandry emphasizes daily human contact, routine treat and toy offerings, visual contact with adjacent pens, elimination of nose to nose contact in young animals, and minimal regrouping to maintain established social hierarchies. The inherent production stresses associated with weaning, animal movement, and regrouping are greatly minimized. The animal flow is tightly controlled and friendly to both animals and people, and ultimately gives you, our client, a superior miniature swine. Sinclair offers four lineages of miniature swine:

• Sinclair™ Miniature Swine

• Micro-Yucatan™ Miniature Swine

• Yucatan™ Miniature Swine

• Hanford™ Miniature Swine

Scientists now have the benefit of the miniature swine strain that best fit their research endeavor. In 2002, Sinclair acquired the Charles River Laboratories miniature swine colonies and the Maine production facility. This strategic acquisition has created a number of possibilities for scientists. Sinclair produces miniature swine from Windham, Maine, and Columbia, Missouri. The Maine site produces micro-Yucatan and Yucatan. The Missouri site produces Sinclair, Hanford, and Yucatan miniature swine. The miniature swine are delivered either in our AAALAC accredited acclimatized trucks or by approved airfreight companies. All animals are well conditioned through a well-established socialization program prior to shipping.

Large Animal Model Production for Your Research Program

Sinclair also specializes in the production of animal models. In fact, Sinclair is the only private company primarily involved in large animal model development. Sinclair has contributed or is experienced in a number of animal models available to our clients, namely:

• Spontaneous Regressing Malignant Melanoma

• White Hairless Miniature Swine for Dermal Studies

• Spontaneous Ventricular Septal Defect (VSD)

• MHC Defined Lineages for Transplantation

• Diabetes Type 1 and 2

• Obesity/Weight Management

• Osteoporosis (4 models)

• Atherosclerosis

• Surgical Modeling

• Orthopedic Modeling

Sinclair continues to offer complete support for the animal sales. Sinclair is very experienced in pre-shipping alterations, which are performed in the spirit of GLP. Common pre-shipping alterations include: vascular access ports placement, high cholesterol diet feeding, diabetes induction, test article administration, biopsies collection for autotransplantation, etc. Furthermore, Sinclair collects a vast array of bio-samples in dogs, cats, miniature swine, and sheep on a daily basis.

Sinclair complies with a number of agencies. We are USDA licensed as a breeder (43-R-2499) and research facility (43-R-0109). We are AAALAC accredited and GLP compliant. The animal care and veterinary program is in compliance with the Guide for the Care and Use of Laboratory Animals. Sinclair has an Assurance Statement filed with PHS.