Sinclair Research Center provides GLP-compliant In Vivo DMPK services from discovery through development in our new state-of-the-art facility near Columbia, Missouri.

Drug Discovery/Drug Development • Radiolabeled and Non-Radiolabeled Test Articles • Blood, Plasma, and Tissue Concentration ¨ • Mass Balance/Excretion (14C & 3H) • QWBA (In Vivo at Sinclair, Sectioning and Analysis Subcontracted)		• Pharmacodynamics • Biliary Excretion (mouse, rat, dog) • Volatile Collection • Metabolic Caging for Multiple Species (rodent, cat, dog, goat, swine)
Pharmacokinetics/Toxicokinetics • Pharmacokinetics/Toxicokinetics ¨ • Single or Multiple Dosing (In-life) • IVGTT, OGTT, & Glucose Clamps		• Bioequivalence & Bioavailability • PK/TK Analysis • Meal Interference/Glycemic Challenge
Routes of Dose Administration • Parenteral (IV/SC/IM/IP) • IV Infusion • Intranasal ¨ Rectal / Intravaginal • Dermal / Intradermal / Transdermal patch • Vascular Access Ports (VAP) • Rodent Vascular and Non-Vascular Cannulas		• Ocular • Auricular • Rectal / Intravaginal • Oral (gavage / liquid / tablet / capsule) • Intracoronary / Intraventricular (percutaneous access)
Test Facility • AAALAC Accredited Facility – Since 1995 • Rodents (Mouse, Rat, Hamster) • Canines • Domestic and Miniature swine (Sinclair, Yucatan, Hanford)		• High Capacity for Small and Large Animals • Rabbits • Felines • Non-Human Primates • Other Species Available
Analytical Support – Alliance Partner Service • Discovery and GLP-compliant bioanalytical chemistry services (SRC Alliance Partner, ABC Pharma Services) • Sample Analysis-Routine Bioanalysis Quantitative Analysis of Drug and Metabolites in Biological Matrices Dose Formulation Analysis, Interference Testing • Analytical Method Development, Validation (Full, Cross, & Partial), Method Transfer & Sample Analysis (LC-MS/MS, HPLC, ICP-MS, EIA, RIA, CZE, and Immunoblots) • Dose Analysis (Radiochemical Purity, Specific Activity) • Metabolite Characterization & Identification • In addition to 14C labeling ABC Laboratories has experience with the following isotopes: 3H, 35S, 32P, 90Y, 111In, 166Ho, 188Re, 99mTc, and others. • Immunoassays ELISA and RIA (125I) Method Development and Validation, Routine Sample Analysis • SRC can also work with the Sponsor’s in-house analytical laboratory or with a Sponsor designated analytical laboratory in support of the studies.