Sinclair Research Center is a contract research organization and an animal production facility. Sinclair specializes in in-life preclinical efficacy testing and the production of animal models. In fact, Sinclair is the only private company primarily involved in large animal model development. Sinclair has contributed or is experienced in a number of animal models available to our clients, namely: Peripheral and Coronary Spontaneous Ventricular Septal Devices Evaluation Defect (VSD) Diabetes type 1 and 2 Obesity Atherosclerosis Osteoporosis (4 models) White Hairless Miniature Swine for Spontaneous Regressing Malignant Dermal Studies Melanoma MHC Defined Lineages for Transplantation Surgical Modeling Sinclair is proud to announce the acquisition of a high-power fluoroscope with cardiovascular support. We are now supporting the evaluation of peripheral and coronary devices, cardiac ischemic models, and local drug delivery evaluation. Sinclair is constructing a complete cardiovascular program for device, drug, and diet evaluation. In 2002, Sinclair acquired the Charles River Laboratories miniature swine colonies and the Maine production facility. This strategic acquisition has created a number of possibilities for scientists. Sinclair, an AAALAC accredited full service research facility, offers three strains of miniature swine, namely the Sinclair, Yucatan (mini and micro), and Hanford. Scientists now have the benefit of the miniature swine strain that best fit their research endeavor. Sinclair produces miniature swine from Windham, Maine, and Columbia, Missouri. The Maine site produces micro-Yucatan and Yucatan. The Missouri site produces Sinclair, Hanford, and Yucatan miniature swine. The miniature swine are delivered either in our AAALAC accredited acclimatized trucks or by approved airfreight companies. All animals are well conditioned through a well-established socialization program prior to shipping. Sinclair continues to offer complete service support for the animal sales. Sinclair is very experienced in pre-shipping alterations, which are performed in the spirit of GLP. Common pre-shipping alterations include: vascular access ports placement, high cholesterol diet feeding, diabetes induction, test article administration, biopsies collection for autotransplantation, etc. Furthermore, Sinclair collects a vast array of bio-samples in dogs, cats, miniature swine, and sheep on a daily basis. Sinclair complies with a number of agencies. We are USDA licensed as a breeder (43-R-2499) and research facility (43-R-0109). We are AAALAC accredited and GLP compliant. The animal care and veterinary program is in compliance with the Guide for the Care and Use of Laboratory Animals. Sinclair has an Assurance Statement filed with PHS.