Pharmacology Research • Range of Species: • Rodents • Rabbits • Large Canine Colony • Miniature Swine • Other Species – Cats, Sheep, Goats, Horses, Poultry, Non-Human Primate • Pharmacokinetics/Bioavailability • Various delivery routes in all animal species including transdermal delivery in miniature swine • Vascular Access Port (VAP) placement in miniature swine for pharmacokinetics • Canine intestinal cannulation • Toxicokinetics • Pharmacodynamics • Metabolism, Tissue Disposition, Biodistribution • Experience with a variety of test articles, including small molecules, proteins and peptides, and anti-neoplastics • Radio labeled and non-radio labeled test articles		Surgical Services • Surgical Model Preparation • Cardiovascular • Coronary and Peripheral Stents • Medical Device • Orthopedics • Wound Healing • Experimental Surgery • Four Surgical Suites • Large Animal Necropsy • Fluoroscopy • Cardio-Ecography, EKG • Color-Doppler Ultrasonography • Body Composition • Bone Density • Safety Pharmacology
Efficacy Research • Diabetes • Obesity • Osteoporosis • Orthopedic • Nutrition • Transdermal Drug Delivery • Reproduction • Pediatrics • Transgenics • Transplantation		Safety Research • General Toxicology • Conventional routes of administration: • Oral • Intravenous - bolus and infusion • Intraperitoneal • Intramuscular • Subcutaneous • Transdermal, dermal • Well experienced in sub-chronic and chronic toxicity • Dermal Irritatin • Target Animal Safety • FDA Redbook Feeding Trials • Safety Pharmacology

Sinclair specializes in comprehensive large-animal support services, particularly for sub-chronic research projects at competitive prices. We excel at developing collaborative teams for complex large-animal projects.