Sinclair Research Center provides GLP-compliant general toxicology services in our new state-of-the-art facility near Columbia, Missouri.

Toxicology Services
• Non-GLP (Discovery) and GLP Studies • Pilot/Range Finding Studies • Acute/Single Dose/MTD • 14-Day and 28-Day Repeat Dose ¨ • Sub-chronic and Chronic Exposures		• Rodent and Non-Rodent • Repeat-Dose Dermal Irritation in Minipigs • Target Animal Safety Studies • FDA Redbook Feeding Trials
Test Facility
• AAALAC Accredited Facility – Since 1995 • Rodents (Mouse, Rat, Hamster) • Canines • Miniature Swine (Sinclair, Yucatan, Hanford)		• Rabbits • Felines • High Capacity for Small and Large Animals • Housing for Other Species Available (goat, sheep, horses, non-human primates)
Routes of Dose Administration
• Parenteral (IV/SC/IM/IP) • IV Infusion • Intranasal • Dermal / Intradermal / Transdermal patch • Vascular Access Ports (VAP)		• Ocular • Auricular • Rectal / Intravaginal • Oral (gavage / liquid / tablet / capsule) • Intracoronary / Intraventricular (percutaneous access)
Supporting Components for Toxicology Studies
• Toxicokinetics • Board Certified Veterinary Ophthalmologist • Board Certified Veterinary Cardiologist		• GLP-Compliant Clinical Pathology • Small and Large Animal Necropsy Suite • Board Certified Veterinary Pathobiologist for Histopathology
Analytical Support – Alliance Partner Service ABC Pharma Services, an SRC Alliance Partner, provides analytical support for our toxicology services. ABC provides a broad range of GLP-complaint chemistry and radiopharmaceutical services in support of In Vivo studies. SRC can also work with the Sponsor’s in-house analytical laboratory or with a Sponsor designated analytical laboratory in support of the studies.