Inflammation

Pathophysiological changes associated with inflammation and disease onset can be modeled in laboratory animals by chemical induction, pharmacological intervention, or surgical modification. Sinclair Research has expanding pharmacology and inflammatory diseases programs, including disease-relevant models of inflammatory joints and osteoarthritis in multiple species. We conduct studies with customized anti-inflammatory drug pharmacodynamic end points to meet each client’s objectives.

Disease Areas

  • Wound healing
  • Rheumatoid arthritis and osteoarthritis
  • Inflammation drugs
  • Joint inflammation
  • Dermal diseases
  • Inflammatory bowel diseases
  • Sepsis and endotoxemia
  • Atherosclerosis

Animal Models

  • Anterior cruciate ligament (ACL)-transection osteoarthritis in rabbits, pigs, and dogs
  • Dermal edema and hypersensitivity in mice
  • Atopic dermatitis in dogs and NHPs
  • Sepsis and endotoxemia in mice, dogs, and NHPs
  • Ulcerative colitis and Crohn’s disease in mice and rats
  • Wound healing in normal and diabetic pigs
  • Atherosclerosis in pigs and rabbits

Pharmacodynamic Assessments

  • Specific clinical disease indexes for functional evaluation of efficacy
  • Fluid and blood cells differential counts
  • Serum and urine chemistry
  • Tissue, fluid, and blood cytokines levels
  • Efficacy and safety biomarkers
  • Histopathology of soft and hard tissues
  • Specific histology-based severity of disease indexes
  • Histomorphometry for tissue damage evaluation
  • Immunohistochemistry of key tissue and inflammatory markers

Applicable Research Areas

  • Dermatology, dermal inflammation, and wound healing
  • Cartilage and joint diseases, osteoarthritis
  • Gastro-intestinal and irritable bowel diseases
Translate »