Metabolic Disease

Metabolic disease and diabetes are ever-growing medical problems in today’s society. Pathophysiological and metabolic changes associated with the onset and development of diabetes mellitus can be modeled in laboratory animals by chemical induction, genetic intervention, or dietary modification. Chemically-induced Type I diabetic miniature swine models have been in use at Sinclair Research for over 10 years. Our staff is very experienced in the area of miniature swine diabetes induction and evaluation of candidate therapeutics. We continually maintain a large herd of diabetic Yucatan miniature swine as a resource for studies. Sinclair has expanded its diabetes and metabolic disease programs, developing other clinically-relevant models in multiple species such as rodents, canines, and NHPs. Glucose tolerance, insulin resistance testing, and insulin potency testing are routinely included in studies.

Animal Models

Spontaneous/Genetic Models:

  • Obesity
  • Metabolic syndrome
  • Hypertension
  • Type II diabetes

Induced Models:

  • Specialized diets
  • Chemicals
  • Surgical
  • Type I & II diabetes

Available Clinical Assessments

  • DEXA analysis
  • Urine chemistry
  • Food and water consumption
  • Serum chemistry
  • Lipid profiles
  • Liver function tests
  • Kidney function profile
  • Hormones and biomarkers
  • Glucose disposal (oGTT and ivGTT)
  • Hyperinsulinemic-glycemic clamp

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