Ocular Studies

Sinclair Research is proud to have assembled an exceptional combination of experience and resources for pre-clinical in-vivo evaluation of ocular therapeutics. We conduct GLP and non-GLP ophthalmic studies ranging from simple to complex design in a variety of animal models for safety, efficacy, drug metabolism and pharmacokinetic (DMPK), and ocular biodistribution evaluations. Whether supporting the development of ophthalmic drugs, devices, or drug-eluting devices, Sinclair is well-equipped to provide clients with required essentials, ranging from technology and facilities to board-certified consultants and ocular histopathology reports, to execute specialized, high-quality studies.

Study Services

  • Ocular toxicology
  • Ocular pharmacology
  • Treatment efficacy
  • Drug-eluting implants
  • Ocular and periocular infection
  • Fundus evaluation
  • Vitreo-retinal surgery
  • ERG
  • Tonometry
  • Digital imaging, anterior and posterior segments
  • Ocular drug distribution
  • Biocompatibility 10993 and 9394 studies

Specialized Animal Models

  • Normal intra-ocular pressure (IOP) in rabbits and NHP
  • Elevated IOP in rabbits, NHPs, and miniature swine
  • Laser-induced glaucoma
  • Miniature swine diabetic retinopathy and cataracts
  • Transgenic retinal degeneration model

Ocular Routes of Administration

  • Topical
  • Intravitreal
  • Intracameral
  • Subretinal injection, including stem cells
  • Subconjunctival
  • Drug-eluting device implantation
  • Punctal plugs

 

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